Medial temporal atrophy (MTA) scoring illustrated on T1weighted MRI.... Download Scientific
Objective To provide age-specific medial temporal lobe atrophy (MTA) cut-off scores for routine clinical practice as marker for Alzheimer's disease (AD). Methods Patients with AD (n = 832, mean age 81.8 years) were compared with patients with subjective cognitive impairment (n = 333, mean age 71.8 years) in a large single-centre memory clinic. Mean of right and left MTA scores was determined.
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MTA correlation with quantitative volumetric methods ranged from -0.20 (p< 0.05) to -0.68 (p < 0.001) depending on the quantitative method used. Both MTA and FreeSurfer are able to distinguish dementia subgroups from CH. Suggested age-dependent MTA thresholds are 1 for the age group below 75 years and 1.5 for the age group 75 years and older.
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A general problem with the MTA score is the inconsist-ently dened cuto value. Various cutos for pathological MTA scores can be found in the literature, diering by age groups and education level. For example, Velickaite and colleagues [8] elaborated that "at age 75, gender and edu-cation are confounders for MTA grading. A score of ≥ 2 is
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MTA-scale for Medial Temporal lobe Atrophy Fazekas scale for WM lesions Normal ageing Strategic infarctions Koedam score for Parietal Atrophy FDG-PET Specific Diseases Alzheimers Disease Presenile AD Mild Cognitive Impairment (MCI) Vascular Dementia (VaD) Strategic infarcts and small vessel disease Cerebral Amyloid Angiopathy (CAA)
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Objective To evaluate the diagnostic performance and reliability of the medial temporal lobe atrophy (MTA) scale in patients with Alzheimer's disease. Methods A systematic literature search of MEDLINE and EMBASE databases was performed to select studies that evaluated the diagnostic performance or reliability of MTA scale, published up to January 21, 2021. Pooled estimates of sensitivity and.
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Usage An ERICA score of 2 or 3 (see below) has been shown to have higher diagnostic accuracy for distinguishing healthy controls with subjective cognitive decline from individuals with Alzheimer disease than the older medial temporal lobe atrophy (MTA) score 1 . diagnostic accuracy = 91% sensitivity = 83% specificity = 98% Imaging
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Scores of MTA correlated to age and Mini-mental state examination score. When used to detect DAT from NC, the MTA showed highest diagnostic value than other scales, and when the cutoff score of 1.5 of MTA scale, it obtained an optimal sensitivity (84.5%) and specificity (79.1%) respectively, with a 15.5% of false negative rate.
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The MTA-score (Scheltens) should be rated on coronal T1-weighted images. on a slice through the corpus of the hippocampus (level of the anterior pons). The scale is based on a visual score of the width of the choroid fissure, the width of the temporal horn, and the height of the hippocampal formation. < 75 years: score 2 or more is abnormal.
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Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer's disease (AD). This study investigated the validity and reliability of MTA in a memory clinic population. MTA was rated in 752 MRI examinations, of which 105 were performed in cognitively healthy participants (CH.
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Abstract. Background: Medial temporal lobe atrophy (MTA) is a sensitive radiologic marker for Alzheimer disease (AD) and associated with cognitive impairment. The value of MTA in the oldest old (>85 years old) is largely unknown.
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Results. Patients with AD had higher MTA scores (mean, 2.13) and ERICA scores (mean, 2.05) than patients with SCD (P < .001).An ERICA score of 2 or greater achieved a higher diagnostic accuracy (91%) than the MTA score (74%), with a sensitivity of 83% versus 57% and a specificity of 98% versus 92% in discriminating dementia caused by AD from SCD (P < .001).
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MTA score: 0: no CSF is visible around the hippocampus (normal); 1: choroid fissure is slightly widened; 2: moderate widening of the choroid fissure, mild enlargement of the temporal horn and mild loss of hippocampal height; 3: marked widening of the choroid fissure, moderate enlargement of the temporal horn, and moderate loss of hippocampal hei.
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Objective The aim of the study is to visually rate major forms of dementia using global cortical atrophy (GCA), medial temporal lobe atrophy (MTA), and Fazeka's scales and Koedam's score using magnetic resonance imaging (MRI). The purpose is to correlate the visual rating scales (VRS) with severity of dementia. Materials and Methods Thirty patients fulfilling DSM 5 (Diagnostic and.
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Medial temporal lobe atrophy (MTA) is considered as a biomarker for Alzheimer's disease (AD) [ 1 - 6] and visual MTA ratings are available for clinical use [ 7 ]. There is debate as to what cut-off scores should be used in clinical practice to optimally differentiate AD from controls without dementia [ 8] or with other types of dementia [ 9, 10 ].
